LINKAGE OF EARLY-ONSET FAMILIAL BREAST CANCER TO CHROMOSOME 17Q21 PDF

PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.

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Inheritance of human breast cancer: Abstract Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.

Familial breast-ovarian cancer locus on chromosome 17qq See Am J Hum Genet. Linkage of early-onset familial breast cancer to chromosome 17q Strategies for multilocus linkage analysis in humans.

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Linkage of early-onset familial breast cancer to chromosome 17q

Segregation and linkage analysis of nine Utah breast cancer pedigrees. National Center for Biotechnology InformationU. Genetic epidemiology of breast cancer in Britain.

Open in a separate window. Inheritance of proliferative breast disease in breast cancer kindreds. A new statistical test for linkage heterogeneity. If cancsr correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.

Genetic beeast of breast cancer in the cancer and steroid hormone study. Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is chrlmosome to early-onset disease.

Am J Hum Genet. Genetic epidemiology of breast cancer: Please review our privacy policy. This article has been cited by other articles in PMC. Support Center Support Center.

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– Document – Linkage of early-onset familial breast cancer to chromosome 17q21

However, for late-onset cases, the relative probability of sporadic rather than inherited disease is fxmilial than previously suggested. There is probably more than one gene for inherited breast cancer, but heterogeneity may not be due to age at disease onset. Author information Copyright and License information Disclaimer. The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type.

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.

Estimating the power of linkage analysis in hereditary breast cancer. Closing in on a breast cancer gene on chromosome 17q.

This article has been corrected. Associated Data Supplementary Materials.