DEVELOPMENTAL FLUORIDE NEUROTOXICITY A SYSTEMATIC REVIEW AND META-ANALYSIS PDF

Objective: We performed a systematic review and meta-analysis of published demiological studies of developmental fluo-. ride neurotoxicity. Developmental Fluoride Neurotoxicity: Choi et al. Respond . fluoride neurotoxicity: a systematic review and meta-. analysis. Environ Health. “Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis” is a study published in Environmental Health.

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Average IQ of children in high-fluorosis area was lower than that in the reference area.

Fluoride exposure was mostly through drinking water, but three studies assessed exposure due to coal burning. Estimates of effect were converted into standardised mean differences SMD and pooled in Mantel-Haenszel fixed-effect and DerSimonian-Laird random-effects meta-analyses. Further subgroup analyses were reported in the paper.

Showing of 76 extracted citations. Commercial Press in Chinese ; The average IQ scores of children residing in the high-fluoride area were lower than those of children residing in the reference area.

The IQ scores of children in the high-fluoride group were significantly lower than those in the reference group. Fluoride released into the ground water in China in some cases greatly exceeded levels that are typical in the U. The current water meta-analhsis level likely also reflects past developmental exposures.

Quantifying heterogeneity in a meta-analysis. The varied and observational nature of the included studies meant that there was a high risk of bias due to confounding factors, so the results may not be reliable.

Modifying effect of COMT gene polymorphism and a predictive role dveelopmental proteomics analysis in children’s intelligence in endemic fluorosis area in Tianjin, China. We rfview searched the China National Knowledge Infrastructure CNKI database, because many studies on fluoride neurotoxicity have been published in Chinese journals only. Smith Environmental health perspectives Information included for each study also included the first author, location of the study, year of publication, defelopmental numbers of participants in high-fluoride and low-fluoride areas.

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The fact that some aspects of the study were not reported limits the extent to which the available reports allow a firm conclusion. Methods of synthesis Estimates of effect were converted into standardised mean differences SMD and pooled in Mantel-Haenszel fixed-effect and DerSimonian-Laird random-effects meta-analyses.

Severe dental fluorosis and cognitive deficits.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis.

The estimate of the between-study variation is incorporated into both the SE of the estimate of the common effect and the weight of individual studies, which was calculated as the inverse sum of the within and between study variance. How Jesus made wine Water woo. Analysis of TSH levels and intelligence of children residing in high fluorosis areas. The effects of endemic fluoride poisoning on the intellectual development of children in Baotou.

When the model was restricted to 9 studies that used the CRT-RC and included only drinking-water fluoride exposure Chen et al.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis – Semantic Scholar

Characteristics devellpmental the 27 studies included are shown in Table 1 An et al. Beurotoxicity were studying fluoride poisoning in China, and it’s irrelevant to any debate over intentional water fluoridation. We did not find conclusive evidence of publication bias, although there was substantial heterogeneity among studies. Thus, children in high-fluoride areas had meta-wnalysis lower IQ scores than those who lived in low-fluoride areas. Use of materials published in EHP should be acknowledged for example,?

More recently published studies gave smaller effect sizes SMD 0. Two cohorts were exposed to fluoride meta-analyis coal burning Guo et al.

Study quality was not formally assessed but the authors noted many quality deficiencies of the studies. The authors of the original meta-analysis published an updated statement on the study in September of that year, [5] underscoring this:.

Chin J Control Endem Dis. We performed a systematic review and meta-analysis of published studies to investigate the effects of increased fluoride exposure and delayed neurobehavioral development. Among the 27 studies, all but one study showed random-effect SMD estimates that indicated an inverse association, ranging from —0.

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Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

So not only were the studies lacking complete information and were limited in scope both of which greatly harm scientific replicatabilitythey were also all conducted in Chinaa country with severely lacking academic freedom from the state as well as having many places where ground water has exceeded safe amounts for consumption. Finally, the sstematic has no application to fluoride levels in U.

In regard to the outcomes, the inverse association persisted between studies using different intelligence tests, although most studies did not report age adjustment of the cognitive test scores.

This article has been cited by other articles in PMC. National Academies Press; syshematic Some methodological limitations were also noted. Although most reports were fairly brief and complete information on covariates was not available, the results tended to support the potential for fluoride-mediated neurotodicity neurotoxicity at relatively high levels of exposure in some studies.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis – RationalWiki

Another study Trivedi et al. Neither can it be used to demonstrate the harmful effects or complete safety, to be fair of municipal fluoridation as the study is better used to examine the systemtaic of fluoride poisoning. The authors did not state how many reviewers performed the data extraction. We carried out an extensive review that includes epidemiological studies carried out in China.

Average IQ score was lower in children in the high-fluoride group than those in the reference group.