THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.
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Epinephrine anti-glaucoma dipivefrin esterase PowerPoint Presentation: Why have such prodrugs if they are not utilised for the purpose of increasing the rate of transportation across the cell membrane? The presentation is successfully added In Your Favorites. Prodrugs to encourage patient acceptance clindamycin antibacterial. Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform.
Another example is when prodrugs may not be susceptible to metabolism in the presystemic passing before entering the target cell, but maybe the drug itself is. Removing substances from the body Some substances are very difficult to eliminate — heavy metals such as lead and mercury The body very efficient.
Examples of Carrier-linked Bipartate Prodrugs 6. Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Enzymes — not just your run of the mill protein!
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Bioprecursor prodrugs: molecular modification of the active principle.
OK Is the passage of drug from its site of administration to its site of action through cell membranes. Cancer Chemotherapy Tumor cells have bioprecursorr much higher growth fraction This translates into higher enzymatic activity that can be exploited Target a prodrug to these sites and exploit higher enzyme activity Example: Phosphorylation Activation ganciclovir substrate for DNA polymerase 5.
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Definition of Bioprecursor Prodrug
Cookies prodfugs us provide you a better browsing experience. Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7.
Bioprecursor Prodrugs – ppt video online download
Phenyl carbamates are rapidly cleaved by plasma enzymes although simple carbamates are generally too stable to hydrolysis. Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7. We think you have liked this presentation. Examples of Carrier-linked Tripartate Prodrugs.
Bioprecursor Prodrugs: Molecular Modification of the Active Principle
Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Bioprecursro and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Share buttons are a little bit lower.
Share buttons are a little bit lower. Suggest an approach to increase the duration of action of Tolmentin Hint: Published by Aubrey Johnston Modified over 3 years ago.
What types of groups are the easiest to cleave from a carrier? About project SlidePlayer Terms of Service. If it were nonspecific, then having the drug administered could cause unwanted side pfodrugs or toxicity before even reaching its target.