BIOPRECURSOR PRODRUGS PDF

THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.

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Epinephrine anti-glaucoma dipivefrin esterase PowerPoint Presentation: Why have such prodrugs if they are not utilised for the purpose of increasing the rate of transportation across the cell membrane? The presentation is successfully added In Your Favorites. Prodrugs to encourage patient acceptance clindamycin antibacterial. Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform.

Another example is when prodrugs may not be susceptible to metabolism in the presystemic passing before entering the target cell, but maybe the drug itself is. Removing substances from the body Some substances are very difficult to eliminate — heavy metals such as lead and mercury The body very efficient.

Examples of Carrier-linked Bipartate Prodrugs 6. Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Enzymes — not just your run of the mill protein!

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My presentations Profile Feedback Log out. If you wish to download it, please recommend it to your friends in any social system. Happiness for me is largely a matter of digestion -Lin Yutang.

Bioprecursor prodrugs: molecular modification of the active principle.

OK Is the passage of drug from its site of administration to its site of action through cell membranes. Cancer Chemotherapy Tumor cells have bioprecursorr much higher growth fraction This translates into higher enzymatic activity that can be exploited Target a prodrug to these sites and exploit higher enzyme activity Example: Phosphorylation Activation ganciclovir substrate for DNA polymerase 5.

Upload from Desktop Single File Upload. Auth with social network: Presentation Description Prodrugs, medicinal chemistry. If you prkdrugs to download it, please recommend it to your friends in any social system.

Registration Forgot your password? Anti-inflammatory drug Tolmetin has a peak plasma concentration of about 1 hr. By using our site, you consent to the use of cookies by us. Understand how a drug candidate can be modified to generate a prodrug 3.

Definition of Bioprecursor Prodrug

Cookies prodfugs us provide you a better browsing experience. Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7.

What the body does to the drug? Disposition of Chemical Compounds. Sum total of ALL chemical reactions in a prodrjgs organism Metabolism is about the energy balance in cells, production. Feedback Privacy Policy Feedback. To make this website work, we log user data and share it with processors. What the body does to the drug?

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Bioprecursor Prodrugs – ppt video online download

Phenyl carbamates are rapidly cleaved by plasma enzymes although simple carbamates are generally too stable to hydrolysis. Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7. We think you have liked this presentation. Examples of Carrier-linked Tripartate Prodrugs.

Bioprecursor Prodrugs: Molecular Modification of the Active Principle

Happiness for me is largely a matter of bioprecuraor -Lin Yutang. Know some examples produgs currently used prodrugs. Disposition of Chemical Compounds. To use this website, you must agree to our Privacy Policyincluding cookie policy.

Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Bioprecursro and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Share buttons are a little bit lower.

Share buttons are a little bit lower. Suggest an approach to increase the duration of action of Tolmentin Hint: Published by Aubrey Johnston Modified over 3 years ago.

What types of groups are the easiest to cleave from a carrier? About project SlidePlayer Terms of Service. If it were nonspecific, then having the drug administered could cause unwanted side pfodrugs or toxicity before even reaching its target.